When it comes to browser homepages, I have slowly drifted from MSN to Google, to Netvibes, to Schoolr, to Sputtr and then back to Google. My latest (and quite possibly greatest) startpage is Only2Clicks.
Only2Clicks is very unique, and I don’t really know what to compare it to. You can create bookmarks of your favorite sites, and they will appear on your page with a screen shot of that page. You can drag-and-drop to reorder, or put bookmarks in a new catagory (page). What I really like about Only2Clicks is that it is basically browser bookmarks, but placed as your start-page make them much more accessible. Also, the visual element makes it easier to navigate if you have many links.
On my page, I have put pages that I do not access enough to warrant being a permanent tab, but that I still access more than once a week. This includes my Google Reader Search, SeeqPod, my Technorati page, Adsense, and MozDev.
So I highly suggest you check out Only2Clicks for your internet start page. Some people argue that Netvibes or iGoogle is the only way to go, but for me, I use Greader for my feeds, I only check the weather when I need to, and I don’t care about the million neat gadgets I could fit on my page.